Regulation of Heat Shock Transcription Factor 1 by Stress-induced SUMO-1 Modification
نویسندگان
چکیده
منابع مشابه
Regulation of HSF1 by stress-induced SUMO-1 modification
Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein (hsp) gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress HSF1 acquires DNA-binding ability and localizes to nuclear stress granules, but the molecular mechanisms which mediate these events are not understood. We report that HSF1 undergoes stress-induced ...
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Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein acetylation, sumoylation and phosphorylation. Upon exposure to stress HSF1 homotrimerizes, accumulates in nucleus, binds DNA, becomes hyper-ph...
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The heat shock response, which is accompanied by a rapid and robust upregulation of heat shock proteins (Hsps), is a highly conserved protection mechanism against protein-damaging stress. Hsp induction is mainly regulated at transcriptional level by stress-inducible heat shock factor 1 (HSF1). Upon activation, HSF1 trimerizes, binds to DNA, concentrates in the nuclear stress granules, and under...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m104714200